2017.07.06 Prism講習会のお知らせ
第32回GraphPad Prism講習会基本操作編および第4回GraphPad Prism講習会(詳細編)の開催日時が決定致しました。お申し込みはフォームから。
2017.05.08 Prism講習会のお知らせ
第31回GraphPad Prism基本操作編の開催日時が決定致しました。お申し込みはフォームから。
2017.04.20 Prism日本語化アドオン7.03(β版)について
2017.04.10 Prism講習会のお知らせ
第30回GraphPad Prism基本操作編および第3回GraphPad Prism講習会[詳細編]の開催日時が決定致しました。お申し込みはフォームから。

ニュースリリース バックナンバー


医療統計ソフト グラフパッドプリズム7

医療統計ソフトGraphPad Prism(グラフパッドプリズム)は、2016年4月4日にGraphPad Prism7がリリースされました。GraphPad Prism7より1つのライセンスでWindows・Mac の両方に対応するようになりました。

GraphPad Prism7の詳細はこちらから

GraphPad Prism7

GraphPad Prism7日本語アドオン

GraphPad Prismのライセンスについて


GraphPad Software Inc.

GraphPad Software

GraphPad Software社は、カリフォルニア大学薬理学部の准教授だったDr. Harvey Motulsky氏によって1984年に創立されました。設立以来、研究者の視点からソフトウェア開発を行い、直感的に操作できるプログラムを世界中の研究者に提供しています。

GraphPad Software, Inc.
7825 Fay Avenue, Suite 230, La Jolla, CA 92037 USA

URL: www.graphpad.com

GraphPad Prism開発者紹介


Dr. Harvey Motulsky

GraphPad Software社は当時、カリフォルニア大学薬理学部の准教授だったDr. Harvey Motulsky氏によって1984年に創立されました。著書である"Intuitive Biostatistics"にもみられる薬理学と生物統計学への造詣の深さが、GraphPad Prismの開発に反映されています。


ntuitive Biostatistics

Intuitive Biostatistics

Oxford University Pressより出版されている"Intuitive Biostatistics "では、データの提示から解析結果の解釈まで、豊富な例を用いて一般的に利用される解析手法の大部分がわかりやすく解説されています。豊富な例示で、日常遭遇する解析手法をほぼ網羅したテキストとなっています。 日本語訳として「数学いらずの医科統計学」(訳者:津崎晃一)が出版されています。


グラフパッドプリズム ユーザー紹介

GraphPad Prismは1984年の発売以来、世界11ヶ国20万人以上の研究者や学生の皆様に利用されています。Prismによる解析結果およびグラフは、医薬関連ジャーナルに投稿される論文だけでなく、国内外の医薬品の特許出願明細書などに数多く用いられています。


Diabetes Care February 2013 vol. 36 no. 2 | February 2013
Closed-Loop Insulin Therapy Improves Glycemic Control in Children Aged <7 YearsA randomized controlled trial- "Statistical analysis was performed using GraphPad Prism version 6.0 for Windows (GraphPad Software, San Diego, CA). Statistical significance was taken as P 0.05; correction... ."詳細
Journal of Trauma Management & Outcomes Volume 6 | 6 August 2012
Late decompressive craniectomyafter traumatic brain injury: neurological outcome at 6 months after ICU discharge - "GraphPad Prism 5 (GraphPad Software Inc., San Diego, CA) was used for statistical analysis. Continuous variables were analyzed with Kruskal-Wallis test and Dunn's multiple comparison test post hoc ."詳細
The Journal of Cell Biology 2012 197:659-675 | Published May 21, 2012
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes - "Statistical analysis Statistical analysis was performed using Prism (GraphPad Software) using the indicated tests."詳細
The Journal of Cell Biology 2012 197:523-534 | Published May 7, 2012
Stoichiometry for binding and transport by the twin arginine translocation system - "Several sigmoidal models were attempted, including Boltzmann Sigmoidal, Sigmoidal dose response with variable slope (Prism 5; GraphPad Software), and a two-consecutive irreversible first-order reaction model (Connors, 1990)."詳細
The Journal of Cell Biology 197:439-455 | Published April 30, 2012
Nonpolarized signaling reveals two distinct modes of 3D cell migration - "All comparisons were performed using Prism5 (GraphPad Software). Differences were considered statistically significant at P 0.05.."詳細
Molecules, Volume 17, Issue 4 (April 2012), p4202
(−)-Kunstleramide, a New Antioxidant and Cytotoxic Dienamide from the Bark of Beilschmiedia kunstleri Gamble - "Figure 5. Dose-response curves (using GraphPad Prism) tested with (−)-kunstleramide (1) and doxorubicin (positive control) in the MTT assays towards (A) A375, (B) A549, (C) HT-29, (D) PC-3 and (E) WRL-68."詳細
JOURNAL OF CLINICAL ONCOLOGY , Vol 30 (March 2012), p490
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease - "statistical analysis: comparisons and correlation between groups were performed by using GraphPad Prism (GraphPad Software, La Jolla, CA)"詳細
Acta Pharmacologica Sinica 33, 148-154 (February 2012)
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities - "Error bars indicate standard deviation of data obtained from three independent experiments. Data analysis and curve fitting were performed with GraphPad Prism 5.0 (GraphPad Software) using a nonlinear regression method (y = [x/(Kd + x)](ymax − ymin) + ymin). " 詳細
Nature Chemistry Volume 4 (February 2012), pg.99–104
A biomimetic polyketide-inspired approach to small-molecule ligand discovery - "Statistical analysis was performed using GraphPad Prism software (GraphPad, San Diego, CA, USA) by one-way analysis of variance (ANOVA), followed by Bonferroni post hoc analysis. " 詳細
PLOS ONE | January 4, 2012
Reduction of Mitoferrin Results in Abnormal Development and Extended Lifespan in Caenorhabditis elegans - "Statistical analyses for body length, brood size, locomotive rate and qRT-PCR were performed by Student's t test. Life span and paraquat sensitivity statistics were analyzed using Kaplan-Meier survival method followed by log-rank test. The Graphpad prism 5 software was used for analysis."詳細
Malaria impairs resistance to Salmonella through heme- and heme oxygenase dependent dysfunctional granulocyte mobilization - "Statistical analyses: We performed statistical analysis using GraphPad Prism 5 software. We used an alpha value of 0.05 for all preplanned statistical analyses. We used the log-rank Mantel Cox test for survival analysis." 詳細
Molecular Cancer Therapeutics | January 2012 11:57-65
Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier - "The curves represent the best fit of data to 4-parameter sigmoidal dose–response equation (Prism, GraphPad)."詳細
PLOS ONE | September 30, 2011
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease - "All data were expressed as mean ± SD. Comparisons of mean among more than three groups were done by one-way or two-way ANOVA, followed by post-hoc test (PRISM, GraphPad software). P values ≤0.05 indicated significant differences ."詳細
Antimicrobial Agents and Chemotherapy | September 2011 vol. 55 no. 9
Knockdown of USP18 Increases Alpha 2a Interferon Signaling and Induction of Interferon-Stimulating Genes but Does Not Increase Antiviral Activity in Huh7 Cells - "Nonlinear regression analysis was used to calculate 50% effective concentrations (EC50s) from each dose-response curve using GraphPad Prism software (version 5.01)."詳細
BMC Medical Genomics 4:38 | 11 May 2011
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment - "Final result is presented as relative expression of the gene relative copy number compared to the mean of the same gene in PBS control group. Results calculated using Excel and graphed in GraphPad Prism."詳細
Clinical Cancer Research | April 1, 2011 17
The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non–Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts - "Expression graphs were used to analyze differences in microRNA expression between cancer tissues and adjacent noncancerous tissues for all qRT-PCR data using Graphpad Prism v5.0 (Graphpad Software, Inc.) Kaplan-Meier analysis was performed using Graphpad Prism v5.0."詳細
PLOS ONE | January 4, 2011
Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line - "Data were analyzed with GraphPad Prism statistical software using two-way ANOVA followed by ad-hoc Bonferroni post-test.."詳細
日本薬理学雑誌, 2011年1月 vo137. No.1 p56
パニツムマブ(ベクティビックス®点滴静注100 mg)の薬理学的特徴および臨床試験成績 -「図2 EGFのA431細胞への結合に対する阻害(社内資料より)結合125I-EGFの平均パーセント/抗体濃度について. Prismソフトウェアで4つのパラメータを持つロジスティック関数を用いて.」詳細
EUROPEAN RESPIRATORY JOURNAL | November 1, 2010 vol. 36 no. 5 1207-1219
The relationship between sarcoidosis and lymphoma - "Group A consisted of cases in which sarcoidosis preceded lymphoma; group B consisted of cases in which the two diseases ... Statistics were calculated using GraphPad Prism 5 software (GraphPad Software, La Jolla, CA, USA)."詳細
Molecular Cancer 2010, 9:299
Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivoq - "Figure 1. Lentiviral vectors designed to achieve equimolar expression of GFP and luciferase. ~ All statistical analyses were performed using GraphPad Prism 5.01." "GraphPad Prism 5.01. Data is the mean ± s.e.m. from 4 independent experiments."詳細
Malaria Journal 2010, 9:208
Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria - "Statistical analysis: All experiments were reproduced at least three times and, where indicated, representative experiments are shown. Statistical analyses were performed with GraphPad Prism 5 software, using 1-way ANOVA test followed by Bonferroni's post hoc test. The significance was indicated as follows: * p < 0.05; ** p < 0.01; *** p < 0.001." 詳細
The Journal of Nuclear Medicine | June 2010 vol. 51 no. 6 942
Preparation, Biological Evaluation, and Pharmacokinetics of the Human Anti-HER1 Monoclonal Antibody Panitumumab Labeled with 86Y for Quantitative PET of Carcinoma - "The percentage injected dose per milliliter of blood was calculated for each of the samples and clearance determined by biphasic nonlinear regression analysis using GraphPad Prism (version 5; GraphPad Software)." "All numeric data were expressed as the mean of the values ± SEM. GraphPad Prism, version 5, was used for statistical analysis. A P value of less than 0.05 was considered statistically significant."詳細
PNAS May 18, 2010 vol. 107
Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine - "The data were analyzed by nonlinear regression and fit to a sigmoid dose–response using GraphPad Prism (GraphPad Software, Inc.)." "The displacement data of the remaining compounds were analyzed by fitting to a one-site competition curve using GraphPad Prism (GraphPad Software, Inc.). Data were acquired in triplicate from three independent experiments and are presented as the mean ± SEM."詳細
PLOS ONE | March 2010 | Volume 5 | Issue 3
Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer - "Ratios of membrane and cytoplasmic signal were analyzed for statistical significance using GraphPad Prism (Kruskal-Wallis test/Dunn's Multiple Comparison Test, p = 0.0052)." " Ratios of nuclear and cytoplasmic signal intensities were analyzed for statistical significance using GraphPad Prism (ANOVA/Dunnett's Multiple Comparison Test, p<0.0001, n = number of cells analyzed)."詳細
Journal of Virology | October 2009 vol. 83 no. 19
Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors - "Data are represented by the mean ± 1 SD for 9 mice from three repeated experiments, as analyzed by GraphPad Prism software version 3.03. *, P < 0.01 by ANOVA test (compared with control mice that received saline)."詳細
日本薬理学雑誌 Vol. 133 (2009) , No. 6 306-310
薬理学研究での統計手法の実態 ─典型的な誤用とその解決方法 - "2002 年:88%,2007 年:78% と減少傾向にはあるものの,2007年でも8割近くの文献で記載がなかった. 記載があったものの中では,SASとGraphPadが゙増加傾向にあった."
Blood | January 22, 2009 vol. 113 no. 4
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis - "The Kaplan-Meier survival curve and statistic analyses were performed using GraphPad Prism4 software (GraphPad Software, San Diego, CA)."詳細
Experimental Biology and Medicine | April 2008 | vol. 233 no. 4 447-455
Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia - "Statistical analysis was calculated using one-way analysis of variance (ANOVA), followed by a Bonferroni posttest or by an unpaired Student t test with GraphPad Prism 5 software."詳細
Clinical and Vaccine Immunology June 2008 vol. 15 no. 6 1012-1018
Enzyme-Linked Immunosorbent Assay for Detection of Plasmodium falciparum Histidine-Rich Protein 2 in Blood, Plasma, and Serum - "A line was drawn for best fit, using the single-line option in the nonlinear analysis package in the GraphPad Prism 5.0 software."詳細
Clinical and Vaccine Immunology June 2008 vol. 15 no. 6 1012-1018
A novel assay to identify entry inhibitors that block binding of HIV-1 gp120 to CCR5E corresponds to the absorbance in experimental group where the test compounds were added before addition of FLSC. EC50 (the concentration for 50% inhibition) values were calculated using the GraphPad Prism software (GraphPad Software Inc., San Diego, CA). "詳細
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